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Lipoic acid may also trigger antioxidant defense, enhance cellular glucose uptake, and modulate the activity of various cell-signaling molecules and transcription factors

Upon activation, IRE1 catalyzes the unconventional splicing of XBP1 mRNA, generating the transcriptionally active XBP1 spliced isoform (XBP1s)

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There may be a role for human leukocyte antigen testing in prevention of severe adverse drug reactions, as shown in the following 2 examples: The HLA-B*5801 allele is associated with a markedly elevated risk of allopurinol hypersensitivity syndrome

Examined in research models for lipid-metabolism pathways

doi: 10.1007/BF01975437 84 YeeDJacksonJGKozelskyTWFigueroaJA