If an underlying primary pathology is responsible, what type of early process could be operating in the area of myelin degeneration that does not exhibit signatures of an autoimmune lymphocytic-driven mechanism, or any detectable infectious or other obvious etiology
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Structure-guided spike design has also been used to identify artificial substitutions in the spike sequence that can increase the expression, solubility, and stability of spike (termed HexaPro) for use as a vaccine antigen [165, 166]
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