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Yasumatsu, N., Matsuzaki M, Noguchi J, and Kasai H (2008)

Buss RW, Kansal PC, Roddam RF, et al

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The overall impression from available evidence is that DSIP appears reasonably well-tolerated with a low incidence of serious adverse effects in the populations and contexts studied, but significant gaps in safety knowledge remain, particularly regarding long-term use, use in specific populations (elderly, children, those with comorbidities), and comprehensive toxicology assessment meeting modern pharmaceutical standards