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Briefly, confirming the protective effects described above -but an an IgE-independent pseudoallergic manner- in a 2,4 Dinitrobenzene (DNCB)-induced atopic dermatitis murine model, formononetin treatment (25, 50 mg/kg) reduced skin lesions, swelling, ear thickness, and mast cell infiltration [125]

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5.2 Pharmacotherapy Targeting Pathogenesis Alpha-Lipoic Acid Since oxidative stress plays a significant role in the pathogenesis of DPN, attention has been focused on antioxidants such as alpha-lipoic acid (ALA) as potential treatments

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