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This is why many people experience a rapid loss of "water weight" in the first few weeks of treatment

Drug-Metabolizing Enzyme- and Transporter- Mediated DDIs of GLP-1 RAs and a Dual GLP-1/GIP RA To date, no clinically relevant drug-metabolizing enzyme- or transporter-mediated DDIs involving GLP-1 RAs or a dual GLP-1/GIP RA have been reported (Table 3)

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Cell Biochem Funct 27:338343

Serious side effects may include vision changes, an allergic reaction, acute pancreatitis, kidney or gallbladder issues, cardiac issues, and drug abuse