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When the cells are exposed to oxidative stress, NRF-2 escapes the negative regulation of KEAP1 through the increase of NRF-2, the transcription of interleukins decreases the levels of antioxidant response elements increase

Chao, A.M

However, despite the widespread use of current therapeutic strategies, both primary and secondary treatment failure rates remain high, indicating that existing therapies continue to have limitations in efficacy and safety, thereby driving the development of new therapeutic targets and approaches

If your kidney function worsens during your treatment, your doctor may have you stop taking this drug

More is not inherently better