Spiegel has more than 40 years of clinical and research experience with hypnosis, stress physiology, and psychotherapy
Expected timeline: Month 1: 4 to 8 pounds lost, primarily appetite-driven deficit Month 2 to 3: 2 to 4 pounds per week sustained loss Month 4 to 6: Continued loss with improved body composition from muscle preservation Protocol 4: the over-40 male optimization stack Goal: Address age-related metabolic slowdown and body composition changes Stack: Tesamorelin: 2mg nightly before bed CJC-1295/ipamorelin: 100mcg/100mcg nightly (can be combined in same injection as tesamorelin) MOTS-c: 10mg weekly Why this works: After 40, GH decline accelerates and mitochondrial function degrades
In addition, recently-approved (2025) sublingual drug Tonmya, was the first new fibromyalgia treatment approved in 15 years
Eskelinen MH, Kivipelto M (2010) Caffeine as a protective factor in dementia and Alzheimers disease
Subsequently, these two cell types segregated into distinct regions while coexisting
Schauer PR, Kashyap SR, Wolski K, Brethauer SA, Kirwan JP, Pothier CE, et al