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Spiegel has more than 40 years of clinical and research experience with hypnosis, stress physiology, and psychotherapy

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Expected timeline: Month 1: 4 to 8 pounds lost, primarily appetite-driven deficit Month 2 to 3: 2 to 4 pounds per week sustained loss Month 4 to 6: Continued loss with improved body composition from muscle preservation Protocol 4: the over-40 male optimization stack Goal: Address age-related metabolic slowdown and body composition changes Stack: Tesamorelin: 2mg nightly before bed CJC-1295/ipamorelin: 100mcg/100mcg nightly (can be combined in same injection as tesamorelin) MOTS-c: 10mg weekly Why this works: After 40, GH decline accelerates and mitochondrial function degrades

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In addition, recently-approved (2025) sublingual drug Tonmya, was the first new fibromyalgia treatment approved in 15 years

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Eskelinen MH, Kivipelto M (2010) Caffeine as a protective factor in dementia and Alzheimers disease

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Subsequently, these two cell types segregated into distinct regions while coexisting

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Schauer PR, Kashyap SR, Wolski K, Brethauer SA, Kirwan JP, Pothier CE, et al

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