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Nat Med (2016) 22(3):23849

Dipeptidyl peptidase-4 (DPP-4) inhibitors increase the bioavailability of both GLP-1 and GIP but the dogma continues to be that it is the increase in GLP-1 that contributes to the improved glucose homeostasis

Diabetes and cancer: 5 years into the recent controversy

Severe kidney or liver disease is not an absolute contraindication, but since MB is extensively metabolized in the liver and about 40% excreted by the kidneys, patients with major organ impairment could accumulate the drug and experience heightened toxicity

Furthermore, the growing medicalization of obesity has perhaps, somewhat paradoxically, led to the emergence of new forms of weight-related stigma

and Lee et al