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Robinson NJ, Winge DR

While the mechanism is not yet proven, there is support for the idea that GLP-1 attenuates the ras homolog gene family, member A (RhoA)/Rho-associated protein kinase (ROCK) signaling pathway, whose activation is known to reduce levels of occludin, claudin-5, and zonula occludens-1 (ZO-1), as well as promote disruption of endothelial tight junctions

Henceforth, the right dosage should be taken into consideration

Increased IGF-1R levels have been detected in many cases of breast malignancy, most often independently of cancer subtype, ER, PR or HER2 status

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