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Therefore, researchers should conduct more in-depth and multifaceted studies to confirm that targeting the HUWE1-TfR1 axis is a new strategy for clinical intervention in ALF

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Pyroptosis Pyroptosis is an inflammatory programmed cell death dependent on caspase-1 activation of Gasdermin D (GSDMD) protein, characterized by cell swelling, rapid plasma membrane rupture, and release of pro-inflammatory cellular contents, playing an important role in heat stress-induced liver injury [54]