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Poor glycemic control can affect kidney function over time, while some diabetes medicationsincluding insulin (which can cause edema regardless of formulation, particularly after initiation or dose intensification) and thiazolidinedionesare known to cause fluid retention

Long-term supplementation with L-carnitine is required to fulfill the body's needs

Bone Issues In bones, high Hcy reduces blood flow, lowers bone mineral density, and increases the risk of osteoporosis and fractures