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For cancers expressing wild-type p53, the strategies most generally involve inhibiting wild-type p53 degradation

It is essential for protecting cells against oxidative stress and damage caused by free radicals

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Cells were transiently transfected using polyethyleneimine (PEI) with 0.25 g of plasmid DNA per well (WT human GIP receptor (E354 variant), human GIP receptor E354Q variant, or empty vector (pcDNA3.1+)) as previously described ( 2.4 cAMP measurement cAMP accumulation in Cos7 cells transfected with the WT or E354Q GIP receptors was measured using the LANCE cAMP detection kit (PerkinElmer Life and Analytical Sciences, MA, United States) as described previously (Woolley et al., 2017)

Acta como un doble agonista de los receptores GIP y GLP-1, optimizando la secrecin de insulina y ralentizando el vaciado gstrico