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Introduction A considerable proportion of people who live in plains will suffer from high-altitude illnesses when they suddenly ascend to an altitude of over 2,500 m without acclimatization, such as acute mountain sickness (AMS), high-altitude pulmonary edema (HAPE), and high-altitude cerebral edema (HACE

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Proton magnetic resonance spectroscopy also showed a decrease in glutamate in the left ventrolateral prefrontal cortex, although these findings were not statistically significant