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Testing may be appropriate if: Weight loss exceeds 1520% Fatigue, hair thinning or neuropathy develops Persistent vomiting or diarrhoea occurs Dietary intake becomes severely restricted You are in a higher-risk group (e.g., premenopausal women, older adults, GLP-1 + metformin users) Monitoring should be personalised rather than automatic

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Zara Cosentino, commenting on the panel's composition, said that while the disclosure of conflicts is a positive transparency measure, it creates a structural problem: "especially when the people who stand to gain from growing access are the ones making the decision." Advisory meetings are subject to federal transparency requirements experts with financial stakes may serve, but relationships must be disclosed and the FDA is expected to explain why the panelist's expertise outweighs the conflict

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