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[DOI] [PubMed] [Google Scholar] 125.Armstrong JS, Jones DP

5-Amino-1-methylquinolinium (5-Amino-1MQ) is a selective small molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme that plays a critical role in cellular metabolism and energy homeostasis

Therefore, targeting SLC7A11 is a promising therapeutic option, and its efficacy can be increased by combining it with drugs that target glutaminolysis 60

doi:10.7326/0003-4819-143-3-200508020-00006

Long-term event-free survival, chimerism and fertility outcomes in 234 patients with sickle-cell anemia younger than 30 years after myeloablative conditioning and matched-sibling transplantation in France