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Under mild-to-moderate oxidative stress in cells, DJ-1 recruitment at the plasma membrane and mitochondria was thought to be the sole way to protect neurons effectively (Maita et al., 2013)

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While NRF2 activates NADPH production through the upregulation of the pentose phosphate pathway, malic enzyme, and isocitrate dehydrogenase, NRF2 also supports cellular NADPH levels by suppressing NADPH-consuming processes

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Twist the needle firmly, but do not overtighten it