As a potent activator of tissue remodeling, it is studied for its ability to modulate the expression of genes involved in wound healing, antioxidant defense, and the synthesis of structural proteins like collagen and elastin
Dysfunction of GPX4 results in the accumulation of lipid peroxides and culminates in ferroptotic cell death
Cyclin D1 promotes mitogen-independent cell cycle progression in hepatocytes
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She has received grants from AstraZeneca, Novo Nordisk, Boehringer Ingelheim, Janssen and Sanofi-Aventis and Eli Lilly