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Example Impacts: F&B Manufacturers: Demand for food and beverage may decrease in the future if the overall calorie consumption of the population drops as a result of the increased use of weight-loss drugs some analysts forecast a 1-3% overall reduction in calorie intake in the U.S
In a study of transgenic mice with a Kras G12D mutation which induces PanINs and eventually pancreatic cancer, treatment with exendin-4 increased higher grade PanIN lesions (35, 38)
Starting at a lower initial dose (for example, 2 mg instead of 4 mg) also helped partially reduce these GI symptoms, andas with other GLP-1 medicationsthe dose was gradually increased over time to improve tolerability
Nor did its effects deteriorate over time (Zander, Madsbad, Madsen, Holst)
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