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Primary endpoints Energy expenditure and RER under indirect calorimetry, fat mass and adipocyte size, liver triglyceride content and histology, plasma lipids, and muscle performance form a coherent endpoint suite tied to ERR biology

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This resulted in 76 ICD-10 codes in women (2465 cases and 1370 controls) and 77 in men (3200 cases and 1871 controls), with 59 codes common to both sexes (see Supplementary Fig