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HMB (beta-hydroxy-beta-methylbutyrate) at about 3 g per day is a second adjunct: it is understood to activate the mTOR (mechanistic target of rapamycin) pathway and inhibit muscle protein breakdown, and a meta-analysis in older adults reported a modest standardized benefit, but the wider evidence is mixed and generally null in trained individuals capable of structured resistance exercise [1]

doi: 10.3389/fimmu.2018.02757 14 NicholsonSEWattsLTBurmeisterDMMerrillDScrogginsSZouYet al

113 PezzoliG.CeredaE.AmamiP.ColosimoS.BarichellaM.SacilottoG.et al (2023)

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