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Blood Sugar Effects Both medications improve glucose metabolism: Liraglutide: HbA1c reduction of 0.5-1.0% at weight loss doses Originally developed for diabetes (Victoza) Modest glucose benefits at Saxenda doses Semaglutide: HbA1c reduction of 1.0-1.8% at diabetes doses Greater glucose improvement than liraglutide Significant benefit for prediabetes and diabetes For patients with diabetes or prediabetes, semaglutide provides greater metabolic benefit
Long-Term Weight Loss Continued treatment with GLP-1 agonists has been associated with sustained weight loss over time
Alcohol reward is increased after Roux-en-Y gastric bypass in dietary obese rats with differential effects following ghrelin antagonism
Check TSH levels 6-8 weeks after starting GLP-1 therapy and after each significant weight milestone
Dose titration is essential for avoiding adverse interactions
This should be done under medical supervision through a program such as JourneyLites medical weight loss program
