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For now, anyone starting one of these drugs should know the range of outcomes is genuinely large, and that being a poor responder is a real possibility

A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis

Gut (1996) 38:9169

Some users report that tirzepatide produces less constipation than semaglutide at equivalent efficacy levels, though head-to-head data is limited

For this reason, any vial that has frozen should be discarded immediately

Before discussing any medication, our team focuses on understanding your health history, current weight, body composition, lifestyle, eating patterns, previous weight loss attempts, medications, lab markers, and risk factors