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Diabetes-induced ER stress activates pro-apoptotic pathways involving C/EBP homologous protein (CHOP), c-Jun N-terminal kinase (JNK), and caspase-12, leading to germ cell apoptosis and impaired spermatogenesis [127, 128]

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77:205964 [PubMed] [Google Scholar] 32.Gaetani GF, Galiano S, Canepa L, Ferraris AM, Kirkman HN

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Addressing these underlying triggers provides a pathway toward improved immune balance and long-term wellness