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Structurally, retatrutide is a synthetic peptide that acts as a triagonist simultaneously engaging three distinct receptor systems: glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors

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Semaglutide has become one of the most discussed compounds in health and wellness globally over the last few years

A Cochrane systematic review of GLP-1 RAs in people with type 2 diabetes revealed HbA 1c reductions of approximately 11 mmol/mol (1.0%) and weight reductions of 1.52.5 kg compared with baseline (Shyangdan et al, 2011)

The researchers included 30 obese patients in a randomized, double-blind, placebo-controlled, two-period crossover experiment over a 12-week period to accomplish this