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PLoS Biol 20:e3001714
Worthington, J
Contact your GP if you experience: Unexpected symptoms after starting B12 supplementation, including persistent skin reactions, gastrointestinal disturbance, or mild allergic manifestations Neurological symptoms such as significant tingling, numbness, weakness, or balance problemsthese may indicate B12 deficiency paradoxically, or alternative neurological conditions requiring assessment Unexplained fatigue or malaise that develops or worsens despite supplementation Concerns about medication interactions , particularly if taking metformin, proton pump inhibitors, or other medications affecting B12 metabolism [2] [4] Seek emergency medical attention (call 999) if you develop signs of a severe allergic reaction following B12 injection, including facial swelling, difficulty breathing, or widespread urticaria
The study was funded by the Italian Diabetes Society and partly supported by a grant from Eli Lilly
It stabilizes intestinal permeability and enhances cytoprotection, making it a promising candidate for mitigating NSAID-induced gastroenteropathy and leaky gut syndrome
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