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Di Girolamo N, Underwood A, McCluskey PJ, Wakefield D

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This evidence indicates that the oxidative stress response is one of the main stress responses caused by chronic hypobaric hypoxia

In the context of ferroptosis, Trx1 supports GPX4 activity and GSH synthesis, and protects mTOR function under oxidative stress, supporting its role as a negative regulator of lipid peroxidation and cell death

Although the human body naturally produces glutathione, factors such as age and poor diet can cause the levels of this essential antioxidant to decrease