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Chelated metals have significantly reduced catalytic activity to decompose hydrogen peroxide and form hydroxyl radicals (Fenton reaction)

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As for SFN, although it was generally safe and well-tolerated in animal models and humans, several side effects were found (i.e., insomnia, vomiting, flatulence, diarrhea, etc.)

[DOI] [PMC free article] [PubMed] [Google Scholar] 60.Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W, Janssen OE, Legro RS, Norman RJ, Taylor AE

Global epidemiology of oral and oropharyngeal cancer