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International Federation of Otohinolaryngological Societies ENT World Congress

Previous GERD history: Any history of acid reflux, hiatal hernia, or esophageal issues before starting tirzepatide

Notably, in B

By mimicking the effects of a natural hormone, Semaglutide increases insulin secretion and decreases glucagon levels, leading to reduced food intake and a sense of fullness

A 2025 meta-analysis published in Frontiers in Pharmacology confirmed this hierarchy, ranking tirzepatide as producing the most significant weight reduction among all available incretin-based therapies, followed by semaglutide, then liraglutide

& Murata, M