Animal research has demonstrated that SN hyperechogenicity is correlated with elevated iron levels and reduced NM levels within the SN (220)
Researchers and regulators are still evaluating the drugs safety, effectiveness and long-term risks before deciding whether to approve it for general use
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The two-electron reducing agent is NADH and the enzyme requires a FAD cofactor close to the active-site Hg-binding cysteines, which operate through a mechanism possibly similar to that of the enzyme glutathione reductase ( vide infra ) [92,93,94]
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De Pessemier B, Grine L, Debaere M, Maes A, Paetzold B, Callewaert C