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GLP-1 and NMDA receptors are expressed throughout the mammalian brain and, although reports indicate that GLP-1 analogues engage central appetite circuits through distinct subpopulations of neurons (most notably in the brainstem and the hypothalamus) 36 , feedforward neural pathways modulated by inhibition of NMDA receptors specifically in GLP-1-receptor-positive neurons may differ from those engaged by exclusive activation of GLP-1 receptors

This dual-phase result is particularly appealing as it provides immediate satisfaction and continued improvement, encouraging clients to return for follow-up sessions

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doi:10.1016/j.npep.2022.102250 110

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