In db/db mice, exendin-4 (EX-4) significantly suppressed the overexpression of pyroptosis-related proteinsincluding ASC, caspase-1, IL-1, and GSDMD
This review summarizes current evidence about the expression and function of intestinal BTRs in relation to enteroendocrine hormone release and discusses the clinical implications of this pathway for the management of obesity and type 2 diabetes
THE RISKS AND THE RED FLAGS Like any medicine, GLP-1 therapy is not risk-free
The main overlap is appetite suppression, which means you need to be intentional about what food you do eat
"Beyond the obvious body composition perspective, what actually matters is reducing the risk of obesity-related disease and complications, as we prioritized in our 2025 AACE Clinical Practice Algorithm," he says
J Mol Neurosci 35(1):81 Park SE, Dantzer R, Kelley KW, McCusker RH (2011) Central administration of insulin-like growth factor-I decreases depressive-like behavior and brain cytokine expression in mice
