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The lipids protect the peptide in multiple ways: gastrointestinal enzymes cant penetrate the lipophilic (fat-loving) shell, the nanoparticles slip through the mucus barrier that normally blocks large molecules, and once they reach the absorption membrane, they can fuse directly with cell membranes or get taken up through lymphatic transport, completely bypassing first-pass liver metabolism

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Plant Physiol 125:292305 Podlekov K, Ugena L, Spchal L, Doleal K, De Diego N (2019) Phytohormones and polyamines regulate plant stress responses by altering GABA pathway