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Dietary polyphenols remodel DNA methylation patterns of NRF2 in chronic disease

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2 Mechanism of action of HDACi in immunotherapy HDAC inhibitors exert complex and multifaceted immunomodulatory effects in a concentration-dependent manner by targeting key immune components in the tumor microenvironment (TME), including the extracellular matrix (ECM), macrophages, T cells, B cells, natural killer cells, and dendritic cells ( Figure 2 )

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Others argue the opposite, that consistent low-dose activation maintains the beneficial signaling