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In a comparable way, the protective role of Numb and galectin-3 proteins against CP injury has been primarily attributed to the inhibition of tubular necroptosis and/or its related inflammatory response (Liu et al., 2020
Mechanistically, GSH depletion does not cause global protein oxidation but instead selectively oxidizes and destabilizes fatty acid synthase while decreasing lipogenic gene expression at the transcriptional level, collectively suppressing lipogenesis
Chen S, Liu Y, Zhong Z, Wei C, Liu Y, Zhu X