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While overall decline rates were similar between groups, post-hoc subgroup analysis indicated slower cognitive decline in early-onset patients (aged 65 or younger) compared to placebo, as measured by the Alzheimer's Disease Assessment Scale cognitive subscale and Clinical Dementia Rating Scale [5][18]

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J Nanobiotechnol 24 , 240 (2026)

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Lu S, Wang J, Chitsaz F, Derbyshire MK, Geer RC, Gonzales NR, et al

Notably, overexpression of MANF or treatment with recombinant human MANF could directly reduce A-induced neuronal apoptosis and ER stress [146]