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NPC1-mTORC1 signaling couples cholesterol sensing to Organelle Homeostasis and is a targetable pathway in Niemann-pick type C

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"As the respiratory organelle, mitochondria produces energy," Birsoy notes

This has mainly derived from experimental studies, although the first results emerged over 30 years ago with the observation of reduced UA in the substantia nigra of PD patients at post mortem 10

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