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Immunohistochemical localization, purification, and characterization of human urinary bladder glutathione S -transferases

In an animal-based study, no significant adverse effects were reported in dogs, who were administered up to 300 mg of glutathione per kg body weight every day for 26 weeks

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2014;3 doi: 10.4103/2277-9175.142314

In severe cases, submassive or massive necrosis may occur

Berberine should be avoided by those who are pregnant or breastfeeding, as it may worsen jaundice in infants or result in kernicterus, a condition in which prolonged high bilirubin levels can cause irreversible effects (28)