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But the results tend to be more durable because the underlying metabolic drivers have changed, not just suppressed

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A few patients were forced to discontinue treatment if the symptoms persisted, and this was unusual

Survodutide Dosing The SYNCHRONIZE Phase 3 trials use a modified escalation protocol designed to improve tolerability compared to Phase 2: Starting dose: Low dose with gradual increases Escalation: Extended titration period with flexibility Target doses: 3.6mg or 6.0mg weekly (SYNCHRONIZE-1) Pause option: Ability to temporarily stop dosing for GI symptoms Time to maintenance: Extended to reduce side effects The inclusion of a pause option in Survodutide trials reflects lessons learned from Phase 2 about the importance of allowing patient-directed tolerance management

Providers evaluate fasting glucose, lipid panels, and metabolic history to confirm indication

Therefore, GLP-1RAs are of great significance in the treatment of NAFLD