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While the pro-inflammatory effect of microcrystalline UA is well-established 3,20 , there are several indications that soluble UA free of UA crystals has protective effects against inflammatory mechanisms and toxicity 50 with effects on macrophage polarisation towards the anti-inflammatory M2 phenotype 51

2023 Jun 29

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These results, while promising, require confirmation in the ongoing Phase 3 programme before any conclusions about comparative efficacy can be drawn