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It can support endothelial survival and induce release of pro-angiogenic factors such as VEGF, MMP-2 and MMP-9 [200,201,202,203]
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Pol Arch Med Wewn 119:478486 Crewe HK, Lennard MS, Tucker GT, Woods FR, Haddock RE (1992) The effect selective serotonin re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes
Myocardial remodelling characterized by fibrosis and hypertrophy, impaired microcirculation, abnormal protein function caused by advanced glycation end products, changes in myocardial metabolism and abnormal mitochondrial function have been noted as associated factors of diabetic cardiomyopathy [14]
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