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Metabolically constrained, potentially reversible dysfunction may be more amenable to strategies that restore mitochondrial fitness (e.g., redox modulation) and support lymphocyte recovery (e.g., IL-7/IL-15), whereas exhaustion-like states may require checkpoint modulation in combination with approaches that target upstream mitochondrial stress and the TOX/NR4Aepigenetic axis
[DOI] [PubMed] [Google Scholar] 228.Kojima M., Kangawa K
But not all methods do equal work
doi: 10.1086/656477 149 MaizelsR
Subsequently, we conducted another review using the keywords "oxidative stress" and "infertility" in specialized literature and confirmed a close relationship between oxidative stress and infertility not only in fish but also in mammals and birds