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Lower concentrations of GABA have been observed in major depression and post-traumatic stress disorder in the brain, and a region of the brain known as the insular cortex that is associated with emotional response.* Lower insula levels of GABA are associated with a significantly higher trait and state anxiety.* GABA, as an inhibitory neurotransmitter, is one of the mediators responsible for reducing the response to fear or anxiety-provoking stimuli.*

Here is how they compare

Bedekovic V, Mise S, Anic T, et al

In plain terms: the strongest direct evidence here is for retatrutide alone

10.1159/00049605330759435 161 Ren H, Qu H, Zhang Y, et al

Severe zinc deficiency is also associated with acrodermatitis enteropathica, a rare autosomal recessive genetic disorder (252)