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The SURPASS-2 trial (A Study of Tirzepatide versus Semaglutide Once Weekly as an Add-On Therapy to Metformin in Participants with Type 2 Diabetes) compared the efficacy of different doses of tirzepatide with semaglutide 1 mg in patients with poorly controlled diabetes on metformin monotherapy

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Clinical trial data from the PIONEER programmewhich evaluated oral semaglutide across diverse patient populationsdid not demonstrate clinically significant elevations in liver transaminases (ALT and AST) compared to placebo or active comparators

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No serious adverse effect was observed in the treatment group