While the body has several antioxidant defense mechanisms, too many free radicals can overwhelm our body and (among other things) impact gene expression, which could lead to inflammation
In the case of ECs, these models are sometimes also referred to as endothelium-on-a-chip, vessel-on-a-chip, or microvasculature-on-a-chip and sometimes require co-culturing ECs with vascular smooth muscle cells, fibroblasts, and other cells [265, 266]
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Researchers utilise BPC-157 to observe how these mechanisms might influence cellular responses to stress or controlled tissue-stress models in controlled, in vitro settings