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Effects of semaglutide on risk of cardiovascular events across a continuum of cardiovascular risk: combined post hoc analysis of the SUSTAIN and PIONEER trials

The benefits often appear before weight loss occurs - cardiovascular risk drops within weeks, kidney function stabilizes, inflammation decreases, insulin sensitivity improves, and even osteoarthritis pain reduces as metabolic health improves

While these medications are mainly associated with improved insulin sensitivity and weight loss, researchers are learning that the benefits of these GLP-1 drugs may go well beyond these effects

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The latest polls report that of the one in eight Americans who have taken a GLP-1 medication, about 38% have only taken them to help lose weight

Diabetes Care 45:23262335