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the discrepancy between the amelioration in the perceived penile erectile function at IIEF-6 questionnaire and the lack of significant changes in the penile vascular function at dynamic PDU in patients with severe vasculogenic ED might be explained by a potential psychological benefit deriving from treatment, mainly represented by a significant improvement of the subjective perceived quality of penile erection, which was not reflected by an objective improvement of the severe underlying organic disease, a discrepancy occasionally reported in the clinical practice

OGTTs were performed at 1300

Nat Commun 15 , 5939 (2024)

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We aimed to achieve high oral bioavailability through high gastrointestinal stability, targeted release at the optimal absorption site, extended serum half-life appropriate for once-daily dosing, and full GLP-1RA potency