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Mild redness, bruising, swelling, or pain at the injection site may occur

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the clinical relevance of this finding in humans is unknown, and in UK and EU prescribing information this is noted as a precaution rather than a formal contraindication but individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (MEN2) should discuss this with their doctor

Therefore, further investigation of its association with disulfidptosis is highly important

The positive correlation in patients between MCT8 mRNA and low tissue T3 levels could suggest that the upregulated MCT8 represents a compensatory mechanism to increase T3 levels in tissues while the circulating T3 concentrations are low