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Moreover, a stable CL1-0/NLS-LCRMP-1 cell line was successfully established, facilitating the localization of LCRMP-1 within the nucleus

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129,136,137,138,139,140 However, clinical translation of saRNAs remains challenging due to the absence of an immune system in xenograft models and the complexity of drug action in the human body

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337 Although all cell types responded to this inhibitor in vitro and showed promising therapeutic effects in vivo, 337 phase I clinical trials for treating advanced solid tumors ultimately failed due to cardiovascular toxicity and wide variability in patient responses