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At the lysosomal membrane, SLC7A11 mediates proton leak, preventing hyperacidity through cystine efflux and Glu influx of lysosomes 140

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Thus, the increase of ATF4-mediated integrated stress response (ISR) in T315I-Bcr-Abl 32D cells remodels dTTP and GSH biosynthesis, thus avoiding DNA replication stress