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By exerting both central and peripheral metabolic regulatory effects, tirzepatide has substantially narrowed the gap between pharmacological and surgical weight loss, representing a significant milestone in the advancement of multi-receptor agonist therapies for obesity [108]

The newly formed citrulline is rapidly recycled to arginine by arginosuccinate synthase and arginosuccinate lyase, making the arginine-citrulline-NO cycle a self-sustaining engine for endothelial homeostasis

How can peptide therapy support recovery in disabilities and injuries

International Journal of Molecular Sciences, 20(21), 5407

Vascular endothelial signalling